What does APAF mean in UNCLASSIFIED

APAF stands for Apoptosis Protease Activating Factor. It is an evolutionary conserved protein that plays a key role in activating caspases, which are the executioners of programmed cell death, also known as apoptosis. APAF has been studied extensively in different types of cells and organisms and has been shown to be associated with many physiological processes such as embryonic development, tissue homeostasis and immune system functioning. Additionally, APAF's function has been implicated in various pathological conditions including cancer and neurological disorders.


APAF meaning in Unclassified in Miscellaneous

APAF mostly used in an acronym Unclassified in Category Miscellaneous that means Apoptosis Protease Activating Factor

Shorthand: APAF,
Full Form: Apoptosis Protease Activating Factor

For more information of "Apoptosis Protease Activating Factor", see the section below.

» Miscellaneous » Unclassified

Role of APAF

APAF is a cytosolic protein that contains two domains – the N-terminal CARD domain and the C-terminal WD40 repeats. The CARD domain interacts with downstream caspase substrates while the WD40 repeats help recruit the specific caspases that will be activated after its interaction with the apoptotic signal receptor. This receptor can be any one of a variety of molecules such as death receptors, mitochondrial membrane proteins and others depending on the type of stimulus triggering the apoptotic cascade. Once interaction occurs between APAF and its receptor, ATP is present which causes a conformational change in both molecules allowing them to interact more tightly leading to dimerization or oligomerization of APAF further facilitating activation of specific proapoptotic caspases like CASP8 or CASP3. In addition to this, certain mitochondrial proteins have also been found to interact with APAF enhancing its action.


The importance of APAF lies not only in its role during normal physiological processes but also in pathological states like cancer where it serves as an important factor modulating tumor cell survival or death depending on stimuli received from surrounding cells or from within. In neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease, too much activation or too little activation of proapoptotic pathways regulated by APAF have both been implicated suggesting great relevance for this molecule in preventing these diseases from progressing further. As such, better understanding of how APAF functions could prove useful in designing therapeutic interventions against some diseases caused by dysregulation of cell death pathways.

Essential Questions and Answers on Apoptosis Protease Activating Factor in "MISCELLANEOUS»UNFILED"

What is Apoptosis Protease Activating Factor?

Apoptosis Protease Activating Factor (APAF) refers to an important cellular regulator of programmed cell death. This protein plays a critical role in controlling the processes of apoptosis and managing the elimination of damaged cells.

What type of molecule is APAF?

APAF is a cellular protein comprising of two distinct domains that works as a receptor. It contains an amino acid sequence known as the Caspase Recruitment Domain, which binds to upstream apoptotic signaling factors, and the CARD domain which recruits downstream caspases into the process.

What is the function of APAF?

The primary function of APAF is to regulate and control apoptotic processes at the cellular level. It does this by initiating an intracellular cascade which eventually leads to the activation of executioner caspases, enzymes responsible for destroying cells for removal from the body or tissue.

How does APAF work?

When activated, APAF binds to upstream signaling factors and recruits downstream caspases into its process. This triggers a cascade where a series of events are set off within cells involving several pathways that lead to cell destruction.

What happens when APAF is not functioning properly?

When APAF is not functioning correctly, it can lead to over-activation or under-activation of apoptosis, resulting in both enhanced and decreased levels of cell destruction. In either case this dysregulation can affect normal physiological processes such as tissue regeneration and repair.

How has research into APAF evolved?

Over time scientists have identified various domains present on APAF proteins and have been able to characterize their individual functions in more detail. This has allowed researchers better understand how these proteins orchestrate complex cell suicide machinery.

Where can I find out more about research into APAF?

There are several scholarly journals dedicated to researching Apoptosis Protease Activating Factor, such as BMC Cell Biology or Annals Of Neurosciences. Online websites such as PubMed provide access to many scientific studies related to this topic.

Is there any other proteins related to APAF?

Yes there are several proteins that work closely with Apoptosis Protease Activating Factor. These include but are not limited to Bcl-2 family members, P53 and NFκB transcription factors among others.

Final Words:
APAF is a crucial molecule involved in regulating apoptotic pathways activated upon receipt of different cellular signals resulting either in programmed cell death or survival depending on context. Its importance lies not just in regulating normal physiological processes but also preventing or even treating certain diseases like cancer and neurodegenerative disorders where it plays an important role at maintaining balance between cellular life and death machinery.

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