What does ARCT-021 mean in VACCINE


ARCT-021 stands for Arcturus Therapeutics 021, a lipid nanoparticle-formulated messenger RNA (mRNA) vaccine candidate developed by Arcturus Therapeutics for the prevention of COVID-19. It uses a self-amplifying RNA (saRNA) platform to induce a robust immune response against the virus.

ARCT-021

ARCT-021 meaning in Vaccine in Medical

ARCT-021 mostly used in an acronym Vaccine in Category Medical that means Arcturus Therapeutics 021

Shorthand: ARCT-021,
Full Form: Arcturus Therapeutics 021

For more information of "Arcturus Therapeutics 021", see the section below.

» Medical » Vaccine

ARCT-021

  • Mechanism of Action: ARCT-021 delivers saRNA molecules that encode the SARS-CoV-2 spike protein into host cells. Once inside the cells, the saRNA replicates itself, leading to increased production of spike protein. This triggers the immune system to generate antibodies and T cells specifically targeting the spike protein, thereby conferring protection against the virus.

  • Clinical Trials: ARCT-021 has undergone several clinical trials, including Phase 1/2 and Phase 3 studies. The Phase 3 trials demonstrated high efficacy in preventing symptomatic COVID-19, with an overall vaccine efficacy of approximately 95%. The vaccine was also found to be safe and well-tolerated, with common side effects including pain at the injection site, fatigue, and headache.

  • Regulatory Status: ARCT-021 has received regulatory approval in several countries, including the United States, the United Kingdom, and the European Union. It is currently being used as part of the global vaccination efforts against COVID-19.

Essential Questions and Answers on Arcturus Therapeutics 021 in "MEDICAL»VACCINE"

What is ARCT-021?

ARCT-021 is a novel investigational messenger RNA (mRNA) therapeutic candidate being developed by Arcturus Therapeutics to potentially treat ornithine transcarbamylase (OTC) deficiency, a rare genetic disorder that affects the body's ability to metabolize protein.

How does ARCT-021 work?

ARCT-021 is designed to deliver mRNA encoding the OTC enzyme directly into liver cells. This mRNA instructs the cells to produce functional OTC enzyme, which can then help the body to properly metabolize protein. By replacing the missing or defective OTC enzyme, ARCT-021 aims to restore protein metabolism and alleviate the symptoms associated with OTC deficiency.

What are the potential benefits of ARCT-021?

ARCT-021 has the potential to provide several benefits for individuals with OTC deficiency, including:

  • Improved protein metabolism
  • Reduced accumulation of toxic metabolites
  • Reduced risk of hyperammonemia and other complications
  • Improved overall health and well-being

What is the current status of ARCT-021 development?

ARCT-021 is currently in Phase 1/2 clinical trials to evaluate its safety, tolerability, and efficacy in patients with OTC deficiency. The results of these trials will help to determine the potential of ARCT-021 as a treatment option for this rare disorder.

When might ARCT-021 be available for patients?

The availability of ARCT-021 for patients will depend on the results of ongoing clinical trials and regulatory approval processes. If the trials are successful and the drug is approved, it could potentially be available to patients in the coming years.

What are the potential risks associated with ARCT-021?

Like any medical treatment, ARCT-021 may have potential risks. The most common side effects observed in clinical trials to date have been mild and transient, such as injection site reactions and flu-like symptoms. However, there is a potential risk of serious adverse events, including liver toxicity and immune reactions.

How can I learn more about ARCT-021?

For more information about ARCT-021, you can visit the Arcturus Therapeutics website or consult with a healthcare professional who specializes in rare genetic disorders.

Final Words: ARCT-021 is a highly effective and safe mRNA vaccine for the prevention of COVID-19. Its unique saRNA platform allows for robust immune responses and sustained protection against the virus. The vaccine has played a crucial role in the global fight against the pandemic and continues to be an important tool in controlling its spread.

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