What does ADME mean in FDA
ADME stands for Absorption, Distribution, Metabolism, and Excretion. These four steps are the physiological processes responsible for the movement of a drug in the body. This article will answer relevant questions about ADME to provide an understanding of how these processes work and their importance to drug therapy efficacy and safety.
ADME meaning of the Abbreviation is...
ADME mostly used in an acronym FDA in Category Governmental that means Absorption, Distribution, Metabolism, and Excretion
Absorption, Distribution, Metabolism, and Excretion
For more information of "Absorption, Distribution, Metabolism, and Excretion", see the section below.
Essential Questions and Answers on Absorption, Distribution, Metabolism, and Excretion in "GOVERNMENTAL»FDA"
What is ADME?
ADME is an acronym standing for Absorption, Distribution, Metabolism, and Excretion. It refers to the four basic steps involved in how drugs move within the body and may be affected by a variety of factors.
What happens during absorption?
During absorption, a drug moves from its point of administration (e.g., oral or intravenous) into circulation so that it can reach its target site in the body. Different routes of administration (e.g., oral vs topical) can impact how quickly and efficiently this process occurs.
What happens during distribution?
Once a drug enters circulation after absorption it begins to distribute throughout the body by binding to proteins such as albumin or globulins. Factors such as blood flow can influence this process; drugs tend to accumulate in areas with high blood flow like muscles and organs because they receive more exposure than those with less vascularization like fat tissue.
What happens during metabolism?
During metabolism or biotransformation, enzymes interact with drugs to chemically alter them in order to increase their solubility so that they can be excreted more easily out of the body through urine or bile. This process helps reduce potentially toxic accumulation of certain drugs in tissues over time which is important for maintaining safe levels within the body.
What happens during excretion?
During excretion drugs are eliminated from circulation via renal elimination (urine) or hepatobiliary elimination (bile). This process requires healthy kidney function as well as intact liver function in order for drugs to be properly removed from circulation and clearance from the body complete.
Knowing about the ADME processes is essential for understanding proper drug dosing and assessing potential hazards related to medication use that could have serious consequences if not addressed promptly before administering a dose to any patient or individual who needs medical treatment using medications or other pharmacological agents
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